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MSK Pain – Improves fatigue

Improves fatigue

Evidence summary

A Cochrane review identified a significant improvement in fatigue in those with fibromyalgia undertaking resistance exercise interventions [1]. Their meta-analysis of two RCTs demonstrated a large improvement in the intervention group, with the Mean Difference -14.66 on a 0-100 scale (-20.55 to -8.77).

Quality of evidence

Moderate quality

Strength of recommendation

Strong recommendation


Regular physical activity that includes a degree of resistance exercise is likely to improve fatigue in those with chronic musculoskeletal pain. There is no evidence to suggest that regular physical activity has a negative impact on fatigue in this population.


1         Busch AJ, Barber KAR, Overend TJ, et al.Exercise for treating fibromyalgia syndrome (Review). Cochrane Database Syst RevPublished Online First: 2007. doi:10.1002/14651858.CD003786.pub2.Copyright