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Cancer – Helps anxiety

Helps anxiety

Evidence summary

During treatment

Meta-analysis demonstrated slight improvement in depression in all cancers, however no clear effect on depression was seen in a systematic review on breast cancer.[4, 10]

2 RCTs and a systematic review have demonstrated no clear change in anxiety levels in studies for all cancer types and breast cancer respectively.[4, 11]

Improved sleep quality was demonstrated from meta-analysis involving walking interventions.[12]

No improvement in quality of life was demonstrated in meta-analysis and systematic reviews for breast or prostate cancer, however for head and neck cancers there was control or improvement.[4, 6, 8]

Quality of evidence

Moderate quality – heterogenous studies with different interventions

Strength of recommendation

Weak – varied due to different outcomes

Conclusion

Depression has been shown to have slight improvement. No change was seen in anxiety. Only walking interventions have been examined for sleep quality and there is a lack of clear evidence for quality of life.

References

Van Moll, C.C., et al., The effect of training during treatment with chemotherapy on muscle strength and endurance capacity: A systematic review. Acta Oncol, 2016. 55(5): p. 539-46.

Stene, G.B., et al., Effect of physical exercise on muscle mass and strength in cancer patients during treatment–a systematic review. Crit Rev Oncol Hematol, 2013. 88(3): p. 573-93.

Buffart, L.M., et al., Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs. Cancer Treat Rev, 2017. 52: p. 91-104.

Furmaniak, A.C., M. Menig, and M.H. Markes, Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database Syst Rev, 2016. 9: p. CD005001.

Baumann, F.T., E.M. Zopf, and W. Bloch, Clinical exercise interventions in prostate cancer patients–a systematic review of randomized controlled trials. Support Care Cancer, 2012. 20(2): p. 221-33.

Gardner, J.R., P.M. Livingston, and S.F. Fraser, Effects of exercise on treatment-related adverse effects for patients with prostate cancer receiving androgen-deprivation therapy: a systematic review. J Clin Oncol, 2014. 32(4): p. 335-46.

Cramp, F. and J. Byron-Daniel, Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev, 2012. 11: p. CD006145.

Capozzi, L.C., et al., The impact of physical activity on health-related fitness and quality of life for patients with head and neck cancer: a systematic review. Br J Sports Med, 2016. 50(6): p. 325-38.

van Haren, I.E., et al., Physical exercise for patients undergoing hematopoietic stem cell transplantation: systematic review and meta-analyses of randomized controlled trials. Phys Ther, 2013. 93(4): p. 514-28.

Craft, L.L., et al., Exercise effects on depressive symptoms in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev, 2012. 21(1): p. 3-19.

Mishra, S.I., et al., Exercise interventions on health-related quality of life for people with cancer during active treatment. Clin Otolaryngol, 2012. 37(5): p. 390-2.

Chiu, H.Y., et al., Walking improves sleep in individuals with cancer: a meta-analysis of randomized, controlled trials. Oncol Nurs Forum, 2015. 42(2): p. E54-62.

Post treatment

Meta-analyses reported an improved quality of life for cancer of all types, and a further meta-analyses showed a small increase in quality of life. [4, 5] No change in quality of life was seen in meta-analysis in lung cancer after resection and colorectal cancer survivors.[3, 6] Slight reductions in depression were demonstrated in a meta-analysis.[7]

Quality of evidence

Moderate quality – quality of life has been grouped together and not divided into different aspects. Quality of life evidence does not exist for post-surgical resection patients in lung cancer, and patients post treatment for colorectal cancer.

Strength of recommendation

Weak

Conclusion

Further work is needed  to examine different aspects of quality of life. It would be reasonable to infer an improvement in quality of life with physical activity. Further studies are needed to understand what dose of physical activity would be beneficial.

References

Cramp, F. and J. Byron-Daniel, Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev, 2012. 11: p. CD006145.

Brown, J.C., et al., Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 2011. 20(1): p. 123-33.

Cramer, H., et al., A systematic review and meta-analysis of exercise interventions for colorectal cancer patients. Eur J Cancer Care (Engl), 2014. 23(1): p. 3-14.

Fong, D.Y., et al., Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ, 2012. 344: p. e70.

Mishra, S.I., et al., Exercise interventions on health-related quality of life for cancer survivors. Cochrane Database Syst Rev, 2012(8): p. CD007566.

Cavalheri, V., et al., Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer. Cochrane Database Syst Rev, 2013(7): p. CD009955.

Craft, L.L., et al., Exercise effects on depressive symptoms in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev, 2012. 21(1): p. 3-19.

Dennett, A.M., et al., Moderate-intensity exercise reduces fatigue and improves mobility in cancer survivors: a systematic review and meta-regression. J Physiother, 2016. 62(2): p. 68-82.