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IRD CTD – Improves Disease activity

Improve disease activity by Moving more:

Whilst there is limited data in relation to physical activity and connective tissues disease, there were improvements seen in disease activity score in patients with Polymyositis and Dermatomyositis with physical activity interventions [1]. Meta-analyses suggest that exercise does not adversely affect disease activity in those with SLE [2].

Quality of evidence:

Grade C – Low  Quality

Strength of recommendation

Grade 2 – Weak Recommendation


There is some evidence that physical intervention improves disease activity in those with Polymyositis and Dermatomyositis, whilst in SLE there is a strong evidence base that exercise does not have a negative effect.


  1. Alemo Munters L, Dastmalchi M, Andgren V, et al. Improvement in health and possible reduction in disease activity using endurance exercise in patients with established polymyositis and dermatomyositis: a multicenter randomized controlled trial with a 1-year open extension followup. Arthritis Care Res (Hoboken). 2013;65(12):1959-1968.
  2. O’Dwyer T, Durcan L, Wilson F. Exercise and physical activity in systemic lupus erythematosus: A systematic review with meta-analyses. Semin Arthritis Rheum. 2017;47(2):204-215.