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IRD AS – Improves mood

Improves mood 

Evidence summary

Low mood and depression can be frequent in people with ankylosing spondylitis [1]. Exercise interventions have been shown to significantly improve depression score and function [2]. Being physical active has been shown to improve self-esteem and quality of life in the general population [3].

Quality of evidence

Moderate quality

Strength of recommendation



While there is only limited evidence that physical activity improves depression scores specifically in people with ankylosing spondylitis, evidence from the general population suggests that physical activity can be recommended to improve mood and self-esteem.


  1. Meesters JJ, Bremander A, Bergman S, Petersson IF, Turkiewicz A, Englund M. The risk for depression in patients with ankylosing spondylitis: a population-based cohort study. Arthritis Res Ther. 2014;16(5):418.
  2. Lim HJ, Moon YI, Lee MS. Effects of home-based daily exercise therapy on joint mobility, daily activity, pain, and depression in patients with ankylosing spondylitis. Rheumatol Int. 2005;25(3):225-229.
  3. Department of Health. Start Active, Stay Active. In: Strategy; 2011.