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IRD CTD – Manage Fatigue

Manage fatigue by Moving more:

Fatigue is a common symptom and can be particularly challenging to manage. Whilst there is limited data in relation to physical activity and connective tissues disease, there is evidence base that physical activity and exercise interventions can help improve fatigue levels in those with SLE[1-3].

Quality of evidence:

Grade B –  Moderate Quality

Strength of recommendation

Grade 1 – Strong Recommendation


Fatigue is a challenging symptom and there is evidence to suggest for those with SLE that physical activity and exercise interventions can help with this symptoms.


  1. O’Dwyer T, Durcan L, Wilson F. Exercise and physical activity in systemic lupus erythematosus: A systematic review with meta-analyses. Semin Arthritis Rheum. 2017;47(2):204-215.
  2. Yuen HK, Cunningham MA. Optimal management of fatigue in patients with systemic lupus erythematosus: a systematic review. Ther Clin Risk Manag. 2014;10:775-786.
  3. Tench CM, McCarthy J, McCurdie I, White PD, D’cruz DP. Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology. 2003 Sep 1;42(9):1050-4.