• In a cross-sectional study of 27 children with epilepsy who have been treated with valproate and/or lamotrigine for 2 or more years, the inactive group had significantly lower body height percentile and lower total bone mineral density (1).
Quality of Evidence
• B – moderate/low quality
Strength of Recommendation
• Grade 2 – weak recommendation
• Inactivity led to significantly lower body height percentile and total BMD in patients on long term valproate and/or lamotrigine in one cross-sectional study. Physical activity could be recommended to mitigate this however more studies are required to build up clinical evidence. Current evidence is limited relating specifically to children with epilepsy.
- Guo et al; Long-term Valproate and Lamotrigine Treatment May be a Marker for Reduced Growth and Bone Mass in Children with Epilepsy. Epilepsia 2001; 42(9): 1141-1147